Wanpeng Li, MD, Hanyu Lu, MD, Huan Wang, MD, Huankang Zhang, MD, Xicai Sun, MD, Li Hu, MD, Weidong Zhao, MD, Yurong Gu, MD, Houyong Li, MD, and Dehui Wang, MD. Despite the advances in radiation therapy techniques, some patients relapse after treatment. The extent of local invasion, regional lymphatic spread, and distant metastasis, as reflected by the TNM staging, are the most important prognostic factors in NPC. The exact cause of nasopharyngeal cancer is unknown, but a number of factors can increase your risk of developing the condition. Certain factors affect prognosis (chance of recovery) and treatment options. If you have the … Whether you or someone you love has cancer, knowing what to expect can help you cope. Background: Patients with metastatic nasopharyngeal carcinoma (NPC) have heterogeneous survival outcomes. We investigated the clinical characteristics, prognostic factors, and post-recurrence prognostic factors of early- and late-recurrence patients for nasopharyngeal carcinoma (NPC) after definitive intensity-modulated radiation therapy (IMRT). , based on 305 patients with nasopharyngeal carcinoma treated with IMRT, showed that the T stage did not affect the LC and OS rates, whereas the N stage was an independent prognostic factor with an impact on OS. To retrospectively analyze the prognosis of patients with nasopharyngeal carcinoma (NPC) initially presenting with liver metastasis, in order to identify independent prognostic factors to facilitate management of treatment. In addition, virus infection has also been reported as a prognostic factor for survival outcomes for head and neck cancers. KW - Nasopharyngeal cancer. Non-keratinizing undifferentiated carcinoma (the most common type in the … Here, we used features of MR images as prognostic factors in patients with advanced nasopharyngeal carcino-ma. Nasopharyngeal carcinoma (NPC) exhibits a distinctive racial and geographic distribution. Conclusion: An improvement in OS with CRT was observed but did not achieve statistical significance. METHODS: Between March 3 rd and April 5 th , 2020, we conducted a retrospective study on a cohort of COVID-19 patients (mild or severe disease) who were hospitalized after presenting to the emergency department (ED) and had at least one positive nasopharyngeal swab … … Radiomics-based prognostic nomograms were devel-oped based on a training cohort (n ¼ 88) using machine learning methods. Many studies have reported varied significant prognostic factors affect the survival of NPC patients. Although risk factors often influence the development of cancer, most do not directly cause cancer. A risk factor is anything that increases a person’s chance of developing cancer. Long term complications and prognostic factors in locally advanced nasopharyngeal carcinoma treated with docetaxel, cisplatin, 5-fluorouracil induction chemotherapy followed by concurrent chemoradiotherapy: A retrospective cohort study. Nasopharyngeal cancer is a disease in which malignant (cancer) cells form in the tissues of the nasopharynx. 651 Dongfeng Road East, 510060 Guangzhou, China (e-mail: guoxiang@sysucc.org.cn) and … The prognostic factor analysis of Han et al. Radiation therapy or concurrent chemoradiation therapy is mainstay for treatment of nasopharyngeal carcinoma. Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is the most common cancer originating in the nasopharynx, most commonly in the postero-lateral nasopharynx or pharyngeal recess (fossa of Rosenmüller), accounting for 50% of cases.NPC occurs in children and adults. Currently, the features and prognosis of nasopharyngeal carcinoma (NPC) with distant metastases are still rarely reported. Examining prognostic factors and patterns of failure in nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy: impact on future clinical trials. However, no information is available about the prognostic factors. Cheng SH, Yen KL, Jian JJ, et al. 2004 Jul 1;22 (13):2643 ... DMR and LRFR were not reduced with AC (P =.34 and.15, respectively). Specifically, the later the N stage is, the worse the prognosis is. Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study J Clin Oncol. We evaluated clinical characteristics and treatment outcomes of nasopharyngeal carcinoma and assessed prognostic factors related to survival. PDF | Introduction Nasopharyngeal carcinoma has the highest metastatic potential of all head and neck cancers. Analyzing the prognostic factors for nasopharyngeal carcinoma, Perez et al. N asophatyngeal carcinoma (NPC) is unique from other head and neck cancers because of its epidemiology, association with the Epstein- Barr virus, and biologic behavior.’ NPC occurs in a younger population, grows rapidly in the local and regional areas, and is highly metastatic. In the coming era of cancer immunotherapy, prognostic factors for LA-NPC need to be further defined using immune-relevant … Background: We previously reported that magnetic resonance imaging evidence of cranial nerve invasion was an unfavourable prognostic factor in nasopharyngeal carcinoma. Background: The purpose of this analysis was to create a prognostic score model for newly diagnosed nasopharyngeal carcinoma (NPC) which has not been created before. KW - Prognostic factor. Some people with several risk factors never develop cancer, while others with no known risk factors do. This study aimed to identify the prognostic factors and failure patterns of non‑meta‑ static nasopharyngeal carcinoma (NPC) in the intensity‑modulated radiotherapy (IMRT) era. BACKGROUND: Nasopharyngeal carcinoma is the third most common cancer among men in Peninsular Malaysia. (A) We applied NMF (k = 5 factors or expression patterns) to analyze the gene expression profiles of nasopharyngeal carcinoma (NPC) samples in the training cohort (n = 113). demonstrated that the most significant prognostic factors in nasopharyngeal carcinoma were patient age, stage of the primary tumor, presence of cervical lymphadenopathy and certain technical factors of irradiation. The authors have no conflicts of interest to disclose. Crossref. Clinical stage is the most important prognostic factor: 5 year disease specific survival is 98% for stage I, 95% for stage II, 86% for stage III and 73% for stage IV Other adverse prognostic factors include older age, male gender, large tumor volume and cranial nerve palsy Case reports. American Journal of Rhinology & Allergy 0 10.1177/1945892420964054 Download Citation. Nasopharyngeal carcinoma Prognostic factors Overall survival Salvage intensity-modulated radiotherapy Meta-analysis ABSTRACT Local recurrence remains a major cause of therapeutic failure in patients with nasopharyngeal carcinoma (NPC) and the effective treatment of recurrent NPC (r-NPC) is still a challenge. Correspondence to: Xing Lv, PhD, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, No. Extended-field radiotherapy for patients with nasopharyngeal carcinoma might contribute to improving their cure-rate, and precise radiation planning is warranted to avoid the late complications such as hearing loss. KEYWORDS: nasopharyngeal carcinoma, prognostic factors, tumor angiogenesis, c-erbB2, immunohistochemistry. The high chemoresponsiveness of NPC is … Nasopharyngeal cancer is a type of head and neck cancer that occurs when cells in the nasopharynx, the upper part of the throat behind the nose and near the base of the skull, grow out of control.. 1,2 More than 70% of new NPC cases were reported in East and Southeast Asia. The prognostic impact of measuring viral load on nasopharyngeal swab specimens (by RT-PCR) is yet to be elucidated. SUBJECTS AND METHOD: We retrospectively reviewed medical records of 87 patients who were treated for nasopharyngeal carcinoma from 1994 … Radiation therapy or concurrent chemoradiation therapy is mainstay for treatment of nasopharyngeal carcinoma. This study aimed to establish an effective prognostic nomogram for patients with NPC with distant metastases using easily determined factors.Methods: The nomogram was based on a retrospective study of 103 patients with metastatic NPC at the First Affiliated Hospital of Xiamen … From basic information about cancer and its causes to in-depth information on specific cancer types – including risk factors, early detection, diagnosis, and treatment options – you’ll find it here. The nasopharynx is the upper part of the pharynx (throat) behind the nose. Most nasopharyngeal cancers are nasopharyngeal carcinoma.There are three types of nasopharyngeal cancer: . The nomograms … We evaluated clinical characteristics and treatment outcomes of nasopharyngeal carcinoma and assessed prognostic factors related to survival. Background: The prognostic values of staging parameters require continual re‑assessment amid changes in diag‑ nostic and therapeutic methods. Nasopharyngeal carcinoma (NPC) has distinct characteristics from other head and neck cancers and accounts for only 0.7% of all cancer cases diagnosed in 2018 globally. Tests that examine the nose and throat are used to detect (find) and diagnose nasopharyngeal cancer. Salvage Endoscopic Nasopharyngectomy in Recurrent Nasopharyngeal Carcinoma: Prognostic Factors and Treatment Outcomes. Prognostic factors of nasopharyngeal carcinoma (NPC) have been one of the most important research foci, and a large number of investigations in this area have been performed and published. Methods: We retrospectively reviewed the medical records of 419 patients with newly diagnosed, nondisseminated, and biopsy proven NPC. Patients were enrolled from the SEER program from 2010 to 2016. 3 The primary … NPC differs significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. 2020;99:49(e23173). Int J Radiat Oncol Biol Phys 2001;50:717-26. This was a single-center retrospective analysis of patients in China from January 2010 to December 2015. Locally advanced nasopharyngeal carcinoma (LA-NPC) is a relatively rare disease in the west but more common in East Asia and areas of the Middle East like Saudi Arabia. KW - Radiotherapy 651 Dongfeng Road East, 510060 Guangzhou, China (e-mail: lvxing@sysucc.org.cn) and Xiang Guo, PhD, Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, No. New prognostic factors in nasopharyngeal carcinoma: Tumor angiogenesis and C ... Jin-Ching Lin, Prognostic Factors in Nasopharyngeal Cancer, Nasopharyngeal Cancer, 10.1007/978-3-540-92810-2_9, (95-136), (2010). The objective of this study was to identify factors with an influence on outcome in patients treated in Hospital Kuala Lumpur. In contrast to other squamous cell carcinoma of the head and neck, nasopharyngeal carcinoma(NPC) is characterized by a high tendency for metastatic dissemination [3].Thirty to 60% of patients with locally advanced disease will develop distant metastasis within five years of diagnosis, while 5 to 8% present with distant metastasis at diagnosis , . Cox model showed CRT to be a favorable prognostic factor for OS (hazard ratio, 0.42; P =.009). Thus, the main purpose of our study was to investigate the metastasis patterns of different histological types of NPC and to clarify the prognostic characteristics of metastases at different sites. 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